Water as a green solvent for fast and efficient synthesis of 1,5-benzodiazepines at room temperature by using Water-Tolerant Sulfonic Acid Nanoreactor Based on Tunable Ordered Porous Silica

Document Type : Original Article

Abstract

 rapid and new green synthesis of 1,5-Benzodiazepines is reported. The title compounds were prepared by the reaction of different 1,2-phenylenediamines and ketones in the presence of ZrOCl₂.8H₂O on montmorillonite K10 and MCM-41-SO₃H as a nanocatalyst in water. These methods are simple, effective, better yield and environmentally friendly.

Keywords

• ZrOCl2.8H2O on Montmorillonite K10
• MCM-41-SO3H
• Heterogeneous catalyst
• 1,5-benzodiazepines

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